Endocrine Abstracts

Many conditions may interfere with intestinal absorption of levothyroxine (L-T4). In addition, it has been demonstrated a failure in the normalisation of TSH values in patients consuming L-T4 tablets with coffee or with water followed by coffee taken shortly afterwards. Recent studies showed that oral liquid L-T4 could remove the problem of L-T4 malabsorption by coffee and f...

Levothyroxine (l-T4) is the mainstay of treating hypothyroidism. Despite the ‘classic’ tablet formulation of l-T4, pharmaceutical industries have recently introduced other formulations such as liquid and a soft gel capsule in a few countries. Recent studies have shown a better absorption of these formulations compared with the traditional tablet bypassing the pH-depending dissolution phase and less suffering the binding by sequestrants in the in...